xPloration® AI-powered B-cell screening for antibody discovery
Screen millions of single B cells and recover thousands of unique antibody variants within hours
OmniAb’s AI-powered xPloration screening incorporates principles of the GEM assay in a high throughput, automated modality. Its through-hole format enables the examination of millions of antibody secreting cells and the proprietary laser recovery method recovers thousands of sequences in minutes.
xPloration uses chips with ~1.5M capillaries to separate individual secreting B-cells in the presence of Reporters. Chips are processed through automated imaging, then analyzed through AI-powered algorithms to identify B-cells that express antibodies with the desired binding profiles. Rapidly recover individual B-cells from selected capillaries by laser injection for processing of B-cell nucleic acids for sequencing and expression cloning.
xPloration enables:
- Bolstered antibody discovery output for partner campaigns using the entire suite of OmniAb transgenic animals
- Optimized antibody discovery efficiency through new types of functional screening assays and large-scale mining of repertoires
