OmniMouse^®: A transgenic mouse for human antibody discovery

OmniMouse expands the sequence diversity of the rat platforms (OmniRat^® and OmniFlic^®), offering easy conversion from wild type mice using the same protocols. Designed with the same transgenes as OmniRat, OmniMouse was launched in 2014. It produces a diverse repertoire of antibodies with human idiotypes and provides a complementary murine system for additional sequence diversity. OmniMouse is bred on a mixed genetic background to increase the sequence diversity. Three lines are available that express different choices of light chain isotypes: kappa, lambda, or kappa and lambda, to provide further diversity. This platform can be easily adapted to internal processes using standard protocols.