Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the different species…
Fully human antibodies from transgenic animals account for an increasing number of new therapeutics. After immunization, diverse human monoclonal antibodies of high affinity…
Human Antibody Production in Transgenic Animals Read More »
Human antibody expression in transgenic rodents has been significantly improved by the integration of large chimeric DNA constructs linking human VH…
Transgenic Animals Derived by DNA Microinjection. Read More »
Expression of human antibody repertoires in transgenic animals has been accomplished by introducing large human Ig loci into mice and, more recently, a chimeric…
Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their functions…
Transgenic chickens expressing human sequence antibodies would be a powerful tool to access human targets and epitopes that have been intractable in mammalian hosts…
Mice transgenic for human Ig loci are an invaluable resource for the production of human Abs. However, such mice often do not yield human mAbs as effectively as conventional…
The rat is a species frequently used in immunological studies but, until now, there were no models with introduced gene-specific mutations. In a recent study, we described for…
Characterization of immunoglobulin heavy chain knockout rats Read More »
The toolbox of rat genetics currently lacks the ability to introduce site-directed, heritable mutations into the genome to create knockout animals. By using engineered zinc-finger…
Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases Read More »
